In several archeological sites in the Berovo area, artefacts & items from the Iron age, roman period as well from the ancient and the middle ages have been found. All of them include rich necropolis findings.
From the Ottoman tax registry of the vilayet of Malesevo in 1621-1622, Berovo is noted as a village with 55 households. By the end of the 19th century Berovo is a small town, with a dominant Christian population and muslims in small percentage.
In the Razlovci village, near Berovo in 1876 the Razlovci rebelion has been raised & lead by Dimitrija Pop Georgiev-Berovski - a legendary Macedonian revolutionary born in Berovo.